Vaccines against intracellular infections requiring cellular immunity

被引：316

作者：

Seder, RA ^{[1
]}

Hill, AVS

机构：

[1] NIAID, Clin Immunol Sect, Clin Invest Lab, NIH, Bethesda, MD 20892 USA

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Inst Mol Med,Mol Immunol Grp, Oxford OX3 9DU, England

来源：

NATURE | 2000年 / 406卷 / 6797期

关键词：

D O I：

10.1038/35021239

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Vaccines against a variety of infectious diseases represent one of the great triumphs of medicine. The immune correlates of protection induced by most current vaccines seem to be mediated by long-lived humoral immune responses. By contrast, there are no currently available vaccines that are uniformly effective for diseases such as HIV, malaria and tuberculosis, in which the cellular immune response might be crucial in mediating protection. Here we examine the mechanisms by which long-lived cellular immune responses are generated and maintained in vivo. We then discuss current approaches for vaccination against diseases in which cellular immune responses are important for protection.

引用

页码：793 / 798

页数：6

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