The rel gene is essential for in vitro growth of Staphylococcus aureus

被引:32
作者
Gentry, D [1 ]
Li, T [1 ]
Rosenberg, M [1 ]
McDevitt, D [1 ]
机构
[1] SmithKline Beecham Pharmaceut, Collegeville, PA 19426 USA
关键词
D O I
10.1128/JB.182.17.4995-4997.2000
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The stringent response in Staphylococcus aureus is mediated by the nucleotide guanosine pentaphosphate, whose synthesis is catalyzed by the product of the rel gene. We report here that the rel gene is essential for the in vitro growth of S. aureus, distinguishing it from all other bacteria tested for this requirement.
引用
收藏
页码:4995 / 4997
页数:3
相关论文
共 17 条
[1]   CLONING THE SPOT GENE OF ESCHERICHIA-COLI - IDENTIFICATION OF THE SPOT GENE-PRODUCT [J].
AN, G ;
JUSTESEN, J ;
WATSON, RJ ;
FRIESEN, JD .
JOURNAL OF BACTERIOLOGY, 1979, 137 (03) :1100-1110
[2]   Cloning and characterization of a bifunctional RelA SpoT homologue from Mycobacterium tuberculosis [J].
Avarbock, D ;
Salem, J ;
Li, LS ;
Wang, ZM ;
Rubin, H .
GENE, 1999, 233 (1-2) :261-269
[3]  
Cashel M., 1996, ESCHERICHIA COLI SAL, V1, P1458
[4]   OCCURRENCE OF THE REGULATORY NUCLEOTIDES PPGPP AND PPPGPP FOLLOWING INDUCTION OF THE STRINGENT RESPONSE IN STAPHYLOCOCCI [J].
CASSELS, R ;
OLIVA, B ;
KNOWLES, D .
JOURNAL OF BACTERIOLOGY, 1995, 177 (17) :5161-5165
[5]   Increase of methicillin resistance in Staphylococcus aureus caused by deletion of a gene whose product is homologous to lytic enzymes [J].
Fujimura, T ;
Murakami, K .
JOURNAL OF BACTERIOLOGY, 1997, 179 (20) :6294-6301
[6]   Mutational analysis of the Escherichia coli spoT gene identifies distinct but overlapping regions involved in ppGpp synthesis and degradation [J].
Gentry, DR ;
Cashel, M .
MOLECULAR MICROBIOLOGY, 1996, 19 (06) :1373-1384
[7]  
HERNANDEZ VJ, 1991, J BIOL CHEM, V266, P5991
[8]   Guanosine pentaphosphate synthetase from Streptomyces antibioticus is also a polynucleotide phosphorylase [J].
Jones, GH ;
Bibb, MJ .
JOURNAL OF BACTERIOLOGY, 1996, 178 (14) :4281-4288
[9]  
Martínez-Costa OH, 1998, J BACTERIOL, V180, P4123
[10]   Functional analysis of a relA/spoT gene homolog from Streptococcus equisimilis [J].
Mechold, U ;
Cashel, M ;
Steiner, K ;
Gentry, D ;
Malke, H .
JOURNAL OF BACTERIOLOGY, 1996, 178 (05) :1401-1411