Paradoxical effect of echinocandins across Candida species in vitro:: Evidence for echinocandin-specific and Candida species-related differences

被引：144

作者：

Chamilos, Georgios

Lewis, Russell E.

Albert, Nathaniel

Kontoyiannis, Dimitrios P.

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Infect Biol, Unit 402, Houston, TX 77030 USA

[2] Univ Texas, Coll Pharm, Houston, TX 77030 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 06期

关键词：

D O I：

10.1128/AAC.00095-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Paradoxical growth of some Candida isolates occurs at concentrations above the MIC for echinocandins. In 60 Candida bloodstream isolates from cancer patients (20 C. albicans isolates and 10 isolates each of C. parapsilosis, C. tropicalis, C. krusei, and C. glabrata), paradoxical growth was more frequent with caspofungin than micafungin or anidulafungin, was unrelated to MIC, and was strikingly absent in C. glabrata isolates.

引用

收藏

页码：2257 / 2259

页数：3

相关论文

共 18 条

[1] Concentration-dependent effects of caspofungin on the metabolic activity of Aspergillus species [J].

Antachopoulos, Charalampos ;

Meletiadis, Joseph ;

Sein, Tin ;

Roilides, Emmanuel ;

Walsh, Thomas J. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (03) :881-887

[2] In vitro activity of caspofungin compared to amphotericin B, fluconazole, and itraconazole against Candida strains isolated in a Turkish University Hospital [J].

Arikan, S ;

Sancak, B ;

Hascelik, G .

MEDICAL MYCOLOGY, 2005, 43 (02) :171-178

[3]

BETTS RF, 2006, 46 INT C ANT AG CHEM

[4]

CHAMILOS G, 2006, 16 C INT SOC HUM AN

[5] Assessment of the paradoxical effect of caspofungin in therapy of candidiasis [J].

Clemons, KV ;

Espiritu, M ;

Parmar, R ;

Stevens, DA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (04) :1293-1297

[6] Echinocandin antifungal drugs [J].

Denning, DW .

LANCET, 2003, 362 (9390) :1142-1151

[7] Characterization of Aspergillus fumigatus mutants with reduced susceptibility to caspofungin [J].

Gardiner, RE ;

Souteropoulos, P ;

Park, S ;

Perlin, DS .

MEDICAL MYCOLOGY, 2005, 43 :S299-S305

[8] Comparison of caspofungin and amphotericin B for invasive candidiasis. [J].

Mora-Duarte, J ;

Betts, R ;

Rotstein, C ;

Colombo, AL ;

Thompson-Moya, L ;

Smietana, J ;

Lupinacci, R ;

Sable, C ;

Kartsonis, N ;

Perfect, J .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (25) :2020-2029

[9] Multiechinocandin- and multiazole-resistant Candida parapsilosis solates serially obtained during therapy for prosthetic valve endocarditis [J].

Moudgal, V ;

Little, T ;

Boikov, D ;

Vazquez, JA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (02) :767-769

[10]

*NAT COMM CLIN LAG, 2002, REF METH BROTH DIL A