Imaging the glutamatergic system in vivo -: relevance to schizophrenia

被引：35

作者：

Bressan, RA

Pilowsky, LS

机构：

[1] Inst Psychiat, London SE5 8AF, England

[2] UCL, Sch Med, Inst Nucl Med, London W1N 8AA, England

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 2000年 / 27卷 / 11期

关键词：

NMDA; schizophrenia; glutamate; positron emission tomography; single-photon emission tomography; ligands;

D O I：

10.1007/s002590000372

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Schizophrenia is a devastating psychiatric illness. Its pathophysiology is not fully clarified. Animal data, in vitro and indirect in vivo imaging support glutamatergic N-methyl-D-aspartate (NMDA) receptor hypofunction in the disorder. A lack of suitable ligands has obstructed direct evaluation of the NMDA receptor hypofunction hypothesis of schizophrenia. Many research groups are working towards developing appropriate single-photon emission tomography and positron emission tomography ligands for the NMDA receptor. This paper briefly presents evidence for links between glutamatergic system dysfunction and schizophrenia. It reviews the radioligands to evaluate glutamatergic receptors in vivo and discusses issues in developing novel ligands for the glutamatergic system.

引用

页码：1723 / 1731

页数：9

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