Magnetic nanoparticles and their applications in medicine

被引:297
作者
Duguet, Etienne
Vasseur, Sebastien
Mornet, Stephane
Devoisselle, Jean-Marie
机构
[1] Univ Bordeaux 1, CNRS, Inst Chim Mat Condensee Bordeaux, F-33608 Pessac, France
[2] Inst Charles Gerhardt, ENSCM, CNRS, UMR UM1 5618, F-34296 Montpellier 5, France
关键词
cancer; drug delivery; hyperthermia; magnetic guidance; magnetic iianoparticle; MRI contrast agent; stealthiness; targeting;
D O I
10.2217/17435889.1.2.157
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Magnetic nanoparticles have attracted attention in modern medicine and pharmacology owing to their potential usefulness as contrast agents for MRI, as colloidal mediators for cancer magnetic hyperthermia or as active constituents of drug-delivery platforms. This review examines these in vivo applications through an understanding of the involved problems and the current and future possibilities for resolving them. A special emphasis is placed upon magnetic nanoparticle requirements from a physical viewpoint (e.g., relaxivity for MRI, specific absorption rate for hyperthermia and magnetic guidance), the factors affecting their biodistribution after intravenous injection (e.g., size and surface hydrophobic/hydrophilic balance) and the solutions envisaged for enhancing their half-life in the blood compartment and in targeting tumor cells.
引用
收藏
页码:157 / 168
页数:12
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