Impact of potassium salts on aromatic substitution reactions

被引：7

作者：

Berglund, RA ^{[1
]}

机构：

[1] Eli Lilly & Co, Tippecanoe Labs, Lafayette, IN 47902 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 1997年 / 1卷 / 04期

关键词：

D O I：

10.1021/op970103a

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Potassium salts, and potassium benzoate in particular, were shown to dramatically accelerate aromatic substitution reactions between a chiral secondary alkoxide and aryl fluoride substrates, There was no loss of chiral purity, and ether yields exceeded those obtained in trials containing no salt additive. The generality of the method was demonstrated by the observation of rate accelerations in several solvents and with several deprotonation bases.

引用

页码：328 / 330

页数：3

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