Alpha-synuclein and transgenic mouse models

被引:138
作者
Fernagut, PO
Chesselet, MF
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Reed Neurol Res Ctr, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Reed Neurol Res Ctr, Los Angeles, CA 90095 USA
关键词
Parkinson disease; Lewy bodies; alpha-syn;
D O I
10.1016/j.nbd.2004.07.001
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Identified as the cause of some familial forms of Parkinson disease (PD) and as one of the major component of Lewy bodies, alpha-synuclein (alpha-syn) became the molecular hallmark of several neurodegenerative conditions now designated as synucleinopathies. Transgenic models have been generated to elucidate its physiological and pathologic roles. Although none of the lines created display dopaminergic neuronal death in the substantia nigra, the models recapitulate some features of synucleinopathies and are useful to study the potential pathogenic role of alpha-synuclein and its molecular partners. This review describes the different alpha-synuclein transgenic models, their clinical relevance to synucleinopathies, and their further utilization to understand the disease process. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:123 / 130
页数:8
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