Anticancer activity of osmium metalla-rectangles

被引：42

作者：

Barry, Nicolas P. E. ^{[1
]}

Edafe, Fabio ^{[2
]}

Dyson, Paul J. ^{[2
]}

Therrien, Bruno ^{[1
]}

机构：

[1] Univ Neuchatel, Inst Chem, CH-2000 Neuchatel, Switzerland

[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

来源：

DALTON TRANSACTIONS | 2010年 / 39卷 / 11期

关键词：

ARENE RUTHENIUM COMPLEXES; PLATINUM; DRUGS; REACTIVITY; BINDING;

D O I：

10.1039/b925015h

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of cationic metalla-rectangles of the general formula [(p-cymene)(4)Os-4(OO boolean AND OO)(2)(N boolean AND N)(2)](4+) have been obtained in methanol from the dinuclear arene osmium precursors [(p-cymene)(2)Os-2(OO boolean AND OO)(2)Cl-2] (OO boolean AND OO = 2,5-dioxydo-1,4-benzoquinonato (dhbq), 2,5-dichloro-1,4-benzoquinonato (dcbq)) by reaction with bipyridine linkers (N boolean AND N = 4,4'-bipyridine, 1,2-bis(4-pyridyl)ethylene) in the presence of AgCF3SO3. All complexes were isolated as triflate salts and characterised by NMR, IR and UV-visible spectroscopy. The cytotoxicities of the dinuclear and tetranuclear osmium complexes were established using ovarian A2780 cancer cell lines. The most active metalla-rectangle, [(p-cymene)(4)Os-4(dhbq)(2)(4,4'-bipyridine)(2)](4+), shows an IC50 value of 5.7 mu M (comparable to cisplatin) against A2780 cancer cells and 7.5 mu M against the cisplatin resistant A2780cisR cells.

引用

页码：2816 / 2820

页数：5

共 35 条

[11] The mechanism of action of platinum anticancer agents-what do we really know about it? [J].

Gibson, Dan .

DALTON TRANSACTIONS, 2009, (48) :10681-10689

[12] Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds [J].

Govender, Preshendren ;

Antonels, Nathan C. ;

Mattsson, Johan ;

Renfrew, Anna K. ;

Dyson, Paul J. ;

Moss, John R. ;

Therrien, Bruno ;

Smith, Gregory S. .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2009, 694 (21) :3470-3476

[13] Phase II study of BBR 3464 as treatment in patients with sensitive or refractory small cell lung cancer [J].

Hensing, Thomas A. ;

Hanna, Nasser H. ;

Gillenwater, Heidi H. ;

Camboni, M. Gabriella ;

Allievi, Cecilia ;

Socinski, Mark A. .

ANTI-CANCER DRUGS, 2006, 17 (06) :697-704

[14] Direct cellular responses to platinum-induced DNA damage [J].

Jung, Yongwon ;

Lippard, Stephen J. .

CHEMICAL REVIEWS, 2007, 107 (05) :1387-1407

[15] A platinum supramolecular square as an effective G-quadruplex binder and telomerase inhibitor [J].

Kieltyka, Roxanne ;

Englebienne, Pablo ;

Fakhoury, Johans ;

Autexier, Chantal ;

Moitessier, Nicolas ;

Sleiman, Hanadi F. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (31) :10040-+

[16]

Lippert B., 1999, CISPLATIN, V5th

[17] Dual triggering of DNA binding and fluorescence via photoactivation of a dinuclear ruthenium(II) arene complex [J].

Magennis, Steven W. ;

Habtemariam, Abraha ;

Novakova, Olga ;

Henry, John B. ;

Meier, Samuel ;

Parsons, Simon ;

Oswald, Iain D. H. ;

Brabec, Viktor ;

Sadler, Peter J. .

INORGANIC CHEMISTRY, 2007, 46 (12) :5059-5068

[18]

Manzotti C, 2000, CLIN CANCER RES, V6, P2626

[19] Synthesis, Molecular Structure, and Anticancer Activity of Cationic Arene Ruthenium Metallarectangles [J].

Mattson, Johan ;

Govindaswamy, Padavattan ;

Renfrew, Anna K. ;

Dyson, Paul J. ;

Stepnicka, Petr ;

Suess-Fink, Georg ;

Therrien, Bruno .

ORGANOMETALLICS, 2009, 28 (15) :4350-4357

[20] Encapsulation of aromatic molecules in hexanuclear arene ruthenium cages: A strategy to build up organometallic carceplex prisms with a dangling arm standing out [J].

Mattsson, Johan ;

Govindaswamy, Padavattan ;

Furrer, Julien ;

Sei, Yoshihisa ;

Yamaguchi, Kentaro ;

Suess-Fink, Georg ;

Therrien, Bruno .

ORGANOMETALLICS, 2008, 27 (17) :4346-4356

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