Substituted 4-methylquinolines as a new class of anti-tuberculosis agents

被引：73

作者：

Jain, R ^{[1
]}

Vaitilingam, B ^{[1
]}

Nayyar, A ^{[1
]}

Palde, PB ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, SAS Nagar 160062, Punjab, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(03)00074-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report synthesis and anti-tuberculosis activities of a series of novel ring-substituted quinolines. The most effective compound of the series 3d (MIC = 6.25 mug/mL, Mycobacterium tuberculosis H37 Rv strain) was synthesized in one step; thus is an attractive lead molecule for anti-tuberculosis drug development. The results of this study represent the discovery of ring-substituted 4-methylquinolines as new class of potential anti-tuberculosis agents. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1051 / 1054

页数：4