Inteins invading mycobacterial RecA proteins

被引：18

作者：

Saves, I

Lanéelle, MA

Daffé, M

Masson, JM

机构：

[1] Univ Toulouse 3, Inst Pharmacol & Biol Struct, CNRS, UMR 5089, F-31077 Toulouse, France

[2] Inst Natl Sci Appl, F-31077 Toulouse, France

来源：

FEBS LETTERS | 2000年 / 480卷 / 2-3期

关键词：

intein; protein splicing; mycobacterium; RecA;

D O I：

10.1016/S0014-5793(00)01944-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five new inteins were discovered in a survey of 39 mycobacterial strains that was undertaken to clarify the role of RecA inteins in mycobacteria, They are all inserted at the RecA-b site of the recA gene of Mycobacterium chitae, M. fallax, M. gastri, M. shimodei and M. thermoresistibile and belong to the MleRecA allelic family. Sequence analysis showed that although only M. tuberculosis harbours an intein at the RecA-a site the sequence of the RecA-b site is well conserved between species. Furthermore, the presence of inteins does not correlate with specific characteristics of the species such as pathogenicity or growth rate. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：221 / 225

页数：5

共 13 条

[1]

Daffe M, 1998, ADV MICROB PHYSIOL, V39, P131

[2] Statistical modeling and analysis of the LAGLIDADG family of site-specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family [J].