New perspectives in aqueous humor secretion and in glaucoma: The ciliary body as a multifunctional neuroendocrine gland

被引:103
作者
Coca-Prados, Miguel [1 ]
Escribano, Julio
机构
[1] Yale Univ, Sch Med, Dept Ophthalmol & Visual Sci, New Haven, CT 06510 USA
[2] Univ Castilla La Mancha, Area Genet, Fac Med, Ctr Reg Invest Biomed, Albacete, Spain
关键词
D O I
10.1016/j.preteyeres.2007.01.002
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
The discovery in the human ocular ciliary body of glaucoma-associated genes (i.e., MYOC, CYP1B1), neuroendocrine processing enzymes, neuroendocrine peptides, steroid-converting enzymes, glutamate transporters, glutamate-metabolizing enzymes, and antiangiogenic factors requires a reevaluation of its function on aqueous humor secretion, intraocular pressure and its role in glaucoma. The ciliary body should be considered as a multifunctional and interactive tissue. The intrinsic hypotensive and/or hypertensive biological activities of many of the endocrine peptides released by the ciliary epithelium are best explained within the context of a neuroendocrine system, linking the inflow and the outflow of aqueous humor. This interpretation is consistent with physiological and genetic studies indicating that changes altering the inflow affects intraocular pressure. In the proposed endocrine system, regulatory peptides secreted by the ciliary epithelium may subserve multiple functions in the following: inflow and outflow pathways of aqueous humor, ciliary blood flow, the immune privilege status of the anterior segment and the diurnal circadian rhythms of aqueous humor secretion and intraocular pressure. These previously unsuspected and challenging functions of the ciliary epithelium should be considered when assessing the multifactorial events which lead to the pathophysiology of glaucoma affecting the outflow pathways of aqueous humor. This review highlights published, and ongoing studies on authors' labs supporting neuroendocrine, steroidogenic and glutamatergic features of the ciliary epithelium and the endocrine communication between the inflow and outflow pathways of aqueous humor. We also discuss how glaucoma-associated genes expressed in the ciliary body and their mutant proteins could influence intraocular pressure, contributing to the development of glaucoma. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:239 / 262
页数:24
相关论文
共 210 条
[41]  
Elo JP, 1996, INT J CANCER, V66, P37, DOI 10.1002/(SICI)1097-0215(19960328)66:1<37::AID-IJC7>3.3.CO
[42]  
2-Q
[43]  
ERICSON L A, 1958, Acta Ophthalmol Suppl, V37, P1
[44]  
Escribano J, 2002, MOL VIS, V8, P315
[45]   ISOLATION AND CHARACTERIZATION OF CELL-SPECIFIC CDNA CLONES FROM A SUBTRACTIVE LIBRARY OF THE OCULAR CILIARY BODY OF A SINGLE NORMAL HUMAN DONOR - TRANSCRIPTION AND SYNTHESIS OF PLASMA-PROTEINS [J].
ESCRIBANO, J ;
ORTEGO, J ;
COCAPRADOS, M .
JOURNAL OF BIOCHEMISTRY, 1995, 118 (05) :921-931
[46]  
Fautsch MP, 2000, INVEST OPHTH VIS SCI, V41, P4163
[47]   Perfusion of his-tagged eukaryotic myocilin increases outflow resistance in human anterior segments in the presence of aqueous humor [J].
Fautsch, MP ;
Bahler, CK ;
Vrabel, AM ;
Howell, KG ;
Loewen, N ;
Teo, WL ;
Poeschla, EM ;
Johnson, DH .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2006, 47 (01) :213-221
[48]  
Fautsch MP, 2001, INVEST OPHTH VIS SCI, V42, P2324
[49]   Type B and type C natriuretic peptide receptors modulate intraocular pressure in the rabbit eye [J].
Fernández-Durango, R ;
Moya, FJ ;
Rípodas, A ;
de Juan, JA ;
Fernández-Cruz, A ;
Bernal, R .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 364 (2-3) :107-113
[50]  
Fernández-Durango R, 2003, MOL VIS, V9, P103