Enzymatic α(2-3)sialylation of non-natural type-I (Lewisc) disaccharides with recombinant sialyl-transferase

被引：14

作者：

Baisch, G ^{[1
]}

Öhrlein, R ^{[1
]}

Streiff, M ^{[1
]}

机构：

[1] NOVARTIS PHARMA AG, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(97)10201-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Recombinant alpha(2-3)sialyl-transferase from rat liver is used to sialylate a series of type-I (Lewis(c)) disaccharides on a preparative scale. The enzyme tolerates a broad array of N-acetyl replacements of the N-glucosamine subunit ranging from small and large lipophilic groups to charged and heterocyclic amides. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：157 / 160

页数：4

共 20 条

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Kittelmann M, 1995, APPL MICROBIOL BIOT, V44, P59

[12] THE USE OF PORCINE LIVER (2-]3)-ALPHA-SIALYLTRANSFERASE IN THE LARGE-SCALE SYNTHESIS OF ALPHA-NEUP5AC-(2-]3)-BETA-D-GALP-(1-]3)-D-GLCPNAC, THE EPITOPE OF THE TUMOR-ASSOCIATED CARBOHYDRATE ANTIGEN CA-50 [J].