Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques

被引:133
作者
Hernandez, Ryan D.
Hubisz, Melissa J.
Wheeler, David A.
Smith, David G.
Ferguson, Betsy
Rogers, Jeffrey
Nazareth, Lynne
Indap, Amit
Bourquin, Traci
McPherson, John
Muzny, Donna
Gibbs, Richard
Nielsen, Rasmus
Bustamante, Carlos D. [1 ]
机构
[1] Cornell Univ, Ithaca, NY 14850 USA
[2] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA
[3] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA
[4] Dept Anthropol, Davis, CA USA
[5] Calif Natl Primate Res Ctr, Davis, CA USA
[6] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Genet Res & Informat Program, Beaverton, OR 97006 USA
[7] Univ Washington, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA
[8] SW Fdn Biomed Res, Dept Genet, San Antonio, TX 78227 USA
[9] Univ Copenhagen, Dept Biol, Ctr Comparat Genom, DK-2100 Copenhagen O, Denmark
关键词
D O I
10.1126/science.1140462
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
To understand the demographic history of rhesus macaques ( Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (r(2) approximate to 0.15 at 10 kilobases) versus Indian (r(2) approximate to 0.52 at 10 kilobases) macaque populations.
引用
收藏
页码:240 / 243
页数:4
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