The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes

被引：241

作者：

Mehlmann, LM ^{[1
]}

Saeki, Y

Tanaka, S

Brennan, TJ

Evsikov, AV

Pendola, FL

Knowles, BB

Eppig, JJ

Jaffe, LA

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Cell Biol, Farmington, CT 06032 USA

[2] Massachusetts Gen Hosp, Charlestown, MA 02129 USA

[3] Deltagen Inc, San Carlos, CA 94070 USA

[4] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

SCIENCE | 2004年 / 306卷 / 5703期

关键词：

D O I：

10.1126/science.1103974

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mammalian oocytes are held in prophase arrest by an unknown signal from the surrounding somatic tells. Here we show that the orphan G(s)-linked receptor GPR3, which is localized in the oocyte, maintains this arrest. Oocytes from Gpr3 knockout mice resume meiosis within antral follicles, independently of an increase in luteinizing hormone, and this phenotype can be reversed by injection of Gpr3 RNA into the oocytes. Thus, the GPR3 receptor is a link in communication between the somatic cells and oocyte of the ovarian follicle and, is crucial for the regulation of meiosis.

引用

页码：1947 / 1950

页数：4