The place of the hippocampus in fear conditioning

被引：225

作者：

Sanders, MJ ^{[1
]}

Wiltgen, BJ ^{[1
]}

Fanselow, MS ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2003年 / 463卷 / 1-3期

关键词：

fear; learning; memory; amygdala; hippocampus; context;

D O I：

10.1016/S0014-2999(03)01283-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pavlovian fear conditioning is a phenomenon amenable to laboratory analysis of the neurobiology of fear and the investigation of neural mechanisms of learning and memory. Investigators have made much progress in delineating the neurocircuitry and neurochemistry of fear conditioning. The place of the hippocampus in context fear remains a controversial issue. In this review, we examine the evidence that the hippocampus plays a role in fear conditioning. We then critically examine hypotheses concerning its exact role in learning and memory for cued and context fear conditioning. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：217 / 223

页数：7

共 34 条

[1]

Adams CE, 1998, J PHARMACOL EXP THER, V287, P760

[2] The hippocampus and pavlovian fear conditioning: Reply to Bast et al. [J].

Anagnostaras, SG ;

Gale, GD ;

Fanselow, MS .

HIPPOCAMPUS, 2002, 12 (04) :561-565

[3] Effects of hippocampal injections of a novel ligand selective for the α5β2γ2 Subunits of the GABA/benzodiazepine receptor on Pavlovian conditioning [J].

Bailey, DJ ;

Tetzlaff, JE ;

Cook, JM ;

He, XH ;

Helmstetter, FJ .

NEUROBIOLOGY OF LEARNING AND MEMORY, 2002, 78 (01) :1-10

[4] The ventral hippocampus and fear conditioning in rats -: Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABAA agonist muscimol [J].

Bast, T ;

Zhang, WN ;

Feldon, J .

EXPERIMENTAL BRAIN RESEARCH, 2001, 139 (01) :39-52

[5] MULTIUNIT CHANGES IN HIPPOCAMPUS AND MEDIAL GENICULATE-BODY IN FREE-BEHAVING RATS DURING ACQUISITION AND RETENTION OF A CONDITIONED-RESPONSE TO A TONE [J].

EDELINE, JM ;

DUTRIEUX, G ;

NEUENSCHWANDERELMASSIOUI, N .

BEHAVIORAL AND NEURAL BIOLOGY, 1988, 50 (01) :61-79

[6]

EICHENBAUM H, 1987, J NEUROSCI, V7, P716

[7]

FANSELOW MS, 1979, B PSYCHONOMIC SOC, V14, P88

[8] Why we think plasticity underlying pavlovian fear conditioning occurs in the basolateral amygdala [J].

Fanselow, MS ;

LeDoux, JE .

NEURON, 1999, 23 (02) :229-232

[9] ACQUISITION OF CONTEXTUAL PAVLOVIAN FEAR CONDITIONING IS BLOCKED BY APPLICATION OF AN NMDA RECEPTOR ANTAGONIST D,L-2-AMINO-5-PHOSPHONOVALERIC ACID TO THE BASOLATERAL AMYGDALA [J].

FANSELOW, MS ;

KIM, JJ .

BEHAVIORAL NEUROSCIENCE, 1994, 108 (01) :210-212

[10] Contextual fear, gestalt memories, and the hippocampus [J].

Fanselow, MS .

BEHAVIOURAL BRAIN RESEARCH, 2000, 110 (1-2) :73-81

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