The first conjugate addition reaction of terminal alkynes catalytic in copper:: Conjugate addition of alkynes in water

被引：141

作者：

Knöpfel, TF ^{[1
]}

Carreira, EM ^{[1
]}

机构：

[1] ETH Honggerberg, Lab Organ Chem, CH-8093 Zurich, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 20期

关键词：

D O I：

10.1021/ja035311z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We document that alkynyl copper reagents generated under aqueous conditions from terminal acetylenes, catalytic Cu(OAc)2, and sodium ascorbate undergo additions to Meldrum's acid-derived Michael acceptors at room temperature (Scheme 1). The additions are not only novel, but also constitute the first example of the conjugate addition reaction of an acetylide catalytic in copper. Copyright © 2003 American Chemical Society.

引用

页码：6054 / 6055

页数：2

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