Initiation of DNA replication in eukaryotic cells

被引：337

作者：

Dutta, A

Bell, SP

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 1997年 / 13卷

关键词：

cell cycle; origin recognition complex; CDC6; MCM proteins; CDC7; DBF4; CDC5; CDC14; CDC45; pre-replicative complex; post-replicative complex; replication licensing; cyclin-dependent kinases; ORIGIN RECOGNITION COMPLEX; CYCLIN-DEPENDENT KINASES; CEREVISIAE CDC6 GENE; PROTEIN-SERINE/THREONINE KINASE; HUMAN NUCLEAR-PROTEIN; XENOPUS EGG EXTRACTS; SACCHAROMYCES-CEREVISIAE; S-PHASE; FISSION YEAST; BUDDING YEAST;

D O I：

10.1146/annurev.cellbio.13.1.293

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The recent identification of proteins that recognize origins of DNA replication and control the initiation of eukaryotic DNA replication has provided critical molecular tools to dissect this process. Dynamic changes in the assembly and disassembly of protein complexes at origins are important for the initiation of DNA replication and occur throughout the cell cycle. Herein, we review the key proteins required for the initiation of DNA replication, their involvement in the protein complex assembly at replication origins, and how the cell cycle machinery regulates this process.

引用

页码：293 / 332

页数：40

共 160 条

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