Anti-inflammatory Agents: Present and Future

被引：817

作者：

Dinarello, Charles A. ^{[1
,2
]}

机构：

[1] Univ Colorado, Dept Med, Aurora, CO 80045 USA

[2] Radboud Univ Nijmegen, Dept Med, Med Ctr, NL-6500 HC Nijmegen, Netherlands

来源：

CELL | 2010年 / 140卷 / 06期

关键词：

HISTONE DEACETYLASE INHIBITOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; TUMOR-NECROSIS-FACTOR; SUBEROYLANILIDE HYDROXAMIC ACID; COLD AUTOINFLAMMATORY SYNDROME; PROINFLAMMATORY CYTOKINE PRODUCTION; JUVENILE IDIOPATHIC ARTHRITIS; ACTIVATED PROTEIN-KINASE; VALPROIC ACID; INFLAMMASOME ACTIVATION;

D O I：

10.1016/j.cell.2010.02.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammatory disorders, neurodegenerative disease, or cancer. A variety of safe and effective anti-inflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories, with many more drugs under development. In particular, the new era of anti-inflammatory agents includes "biologicals" such as anticytokine therapies and small molecules that block the activity of kinases. Other anti-inflammatories currently in use or under development include statins, histone deacetylase inhibitors, PPAR agonists, and small RNAs. This Review discusses the current status of anti-inflammatory drug research and the development of new anti-inflammatory therapeutics.

引用

页码：935 / 950

页数：16

共 106 条

[1] Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction [J].

Abbate, Antonio ;

Salloum, Fadi N. ;

Vecile, Elena ;

Das, Anindita ;

Hoke, Nicholas N. ;

Straino, Stefania ;

Biondi-Zoccai, Giuseppe G. L. ;

Houser, Jon-Erik ;

Qureshi, Ian Z. ;

Ownby, Evan D. ;

Gustini, Edoardo ;

Biasucci, Luigi M. ;

Severino, Anna ;

Capogrossi, Maurizio C. ;

Vetrovec, George W. ;

Crea, Filippo ;

Baldi, Alfonso ;

Kukreja, Rakesh C. ;

Dobrina, Aldo .

CIRCULATION, 2008, 117 (20) :2670-2683

[2] Interleukin-1 Blockade With Anakinra to Prevent Adverse Cardiac Remodeling After Acute Myocardial Infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot Study) [J].

Abbate, Antonio ;

Kontos, Michael C. ;

Grizzard, John D. ;

Biondi-Zoccai, Giuseppe G. L. ;

Van Tassell, Benjamin W. ;

Robati, Roshanak ;

Roach, Lenore M. ;

Arena, Ross A. ;

Roberts, Charlotte S. ;

Varma, Amit ;

Gelwix, Christopher C. ;

Salloum, Fadi N. ;

Hastillo, Andrea ;

Dinarello, Charles A. ;

Vetrovec, George W. .

AMERICAN JOURNAL OF CARDIOLOGY, 2010, 105 (10) :1371-1377

[3] An Autoinflammatory Disease with Deficiency of the Interleukin-1-Receptor Antagonist [J].

Aksentijevich, Ivona ;

Masters, Seth L. ;

Ferguson, Polly J. ;

Dancey, Paul ;

Frenkel, Joost ;

van Royen-Kerkhoff, Annet ;

Laxer, Ron ;

Tedgard, Ulf ;

Cowen, Edward W. ;

Pham, Tuyet-Hang ;

Booty, Matthew ;

Estes, Jacob D. ;

Sandler, Netanya G. ;

Plass, Nicole ;

Stone, Deborah L. ;

Turner, Maria L. ;

Hill, Suvimol ;

Butman, John A. ;

Schneider, Rayfel ;

Babyn, Paul ;

El-Shanti, Hatem I. ;

Pope, Elena ;

Barron, Karyl ;

Bing, Xinyu ;

Laurence, Arian ;

Lee, Chyi-Chia R. ;

Chapelle, Dawn ;

Clarke, Gillian I. ;

Ohson, Kamal ;

Nicholson, Marc ;

Gadina, Massimo ;

Yang, Barbara ;

Korman, Benjamin D. ;

Gregersen, Peter K. ;

van Hagen, P. Martin ;

Hak, A. Elisabeth ;

Huizing, Marjan ;

Rahman, Proton ;

Douek, Daniel C. ;

Remmers, Elaine F. ;

Kastner, Daniel L. ;

Goldbach-Mansky, Raphaela .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (23) :2426-2437

[4] Phospholipases C and A2 control lysosome-mediated IL-1β secretion:: Implications for inflammatory processes [J].

Andrei, C ;

Margiocco, P ;

Poggi, A ;

Lotti, LV ;

Torrisi, MR ;

Rubartelli, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (26) :9745-9750

[5] Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells [J].

Archin, Nancy M. ;

Eron, Joseph J. ;

Palmer, Sarah ;

Hartmann-Duff, Anne ;

Martinson, Jeffery A. ;

Wiegand, Ann ;

Bandarenko, Nicholas ;

Schmitz, John L. ;

Bosch, Ronald J. ;

Landay, Alan L. ;

Coffin, John M. ;

Margolis, David M. .

AIDS, 2008, 22 (10) :1131-1135

[6] Rab39a Binds Caspase-1 and Is Required for Caspase-1-dependent Interleukin-1β Secretion [J].

Becker, Christine E. ;

Creagh, Emma M. ;

O'Neill, Luke A. J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (50) :34531-34537

[7] Expression and localization of IL-1β mRNA is interrelated with cytoskeletal rearrangement in monocytes stimulated by adherence:: A light microscopy in situ hybridization study [J].

Böcker, U ;

Sirenko, OI ;

Morris, JS ;

Sartor, RB ;

Singer, MV ;

Haskill, JS ;

Watson, JM .

IMMUNOLOGY AND CELL BIOLOGY, 2001, 79 (05) :444-453

[8] Caspase-1-dependent processing of pro-interleukin-1β is cytosolic and precedes cell death [J].

Brough, David ;

Rothwell, Nancy J. .

JOURNAL OF CELL SCIENCE, 2007, 120 (05) :772-781

[9]

Charles P, 1999, J IMMUNOL, V163, P1521

[10] Converting enzyme-independent release of tumor necrosis factor α and IL-1β from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3 [J].

Coeshott, C ;

Ohnemus, C ;

Pilyavskaya, A ;

Ross, S ;

Wieczorek, M ;

Kroona, H ;

Leimer, AH ;

Cheronis, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (11) :6261-6266

← 1 2 3 4 5 6 7 8 9 10 →