Anti-inflammatory Agents: Present and Future

被引：817

作者：

Dinarello, Charles A. ^{[1
,2
]}

机构：

[1] Univ Colorado, Dept Med, Aurora, CO 80045 USA

[2] Radboud Univ Nijmegen, Dept Med, Med Ctr, NL-6500 HC Nijmegen, Netherlands

来源：

CELL | 2010年 / 140卷 / 06期

关键词：

HISTONE DEACETYLASE INHIBITOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; TUMOR-NECROSIS-FACTOR; SUBEROYLANILIDE HYDROXAMIC ACID; COLD AUTOINFLAMMATORY SYNDROME; PROINFLAMMATORY CYTOKINE PRODUCTION; JUVENILE IDIOPATHIC ARTHRITIS; ACTIVATED PROTEIN-KINASE; VALPROIC ACID; INFLAMMASOME ACTIVATION;

D O I：

10.1016/j.cell.2010.02.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammatory disorders, neurodegenerative disease, or cancer. A variety of safe and effective anti-inflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories, with many more drugs under development. In particular, the new era of anti-inflammatory agents includes "biologicals" such as anticytokine therapies and small molecules that block the activity of kinases. Other anti-inflammatories currently in use or under development include statins, histone deacetylase inhibitors, PPAR agonists, and small RNAs. This Review discusses the current status of anti-inflammatory drug research and the development of new anti-inflammatory therapeutics.

引用

页码：935 / 950

页数：16

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