Rapid Sequencing of Individual DNA Molecules in Graphene Nanogaps

被引：325

作者：

Postma, Henk W. Ch. ^{[1
]}

机构：

[1] Calif State Univ Northridge, Dept Phys, Northridge, CA 91330 USA

来源：

NANO LETTERS | 2010年 / 10卷 / 02期

关键词：

DNA; sequencing; graphene; SINGLE-STRANDED-DNA; ELECTRIC-FIELD; NANOPORE; TRANSLOCATION; DISCRIMINATION; GRAPHITE; ENERGY; ROUTE; ACID;

D O I：

10.1021/nl9029237

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

I propose a technique for reading the base sequence of a single DNA molecule using a graphene nanogap to read the DNA's transverse conductance. Because graphene is a single atom thick, single-base resolution of the conductance is readily obtained. The nonlinear current-voltage characteristic is used to determine the base type independent of nanogap-width variations that cause the current to change by 5 orders of magnitude. The expected sequencing error rate is 0% up to a nanogap width of 1.6 nm.

引用

页码：420 / 425

页数：6

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