Antigen-presenting capability of glial cells under glioma-harboring conditions and the effect of glioma-derived factors on antigen presentation

被引:28
作者
Taniguchi, Y [1 ]
Ono, K [1 ]
Yoshida, S [1 ]
Tanaka, R [1 ]
机构
[1] Niigata Univ, Brain Res Inst, Dept Neurosurg, Niigata 9518585, Japan
关键词
microglia; astrocyte; antigen-presenting capability; rat glioma;
D O I
10.1016/S0165-5728(00)00361-1
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The antigen-presenting capability of syngeneic rat glial cells was investigated under glioma-harboring conditions. Microglia induced a significant proliferation of glioma-primed splenocytes, but astrocytes did not. Furthermore, astrocytes suppressed the accessory cell function of microglia. The presence of both indomethacin and anti-interleukin (IL)-10 neutralizing antibody during priming of microglia enhanced splenocyte proliferation. The glioma culture supernatants down-regulated the interferon-gamma -induced expression of major histocompatibility complex class LI molecules on microglia. The down-regulation was blocked by indomethacin and anti-IL-10 antibody. The results suggest that microglia but not astrocytes may function as antigen-presenting cells in glioma, and that glioma may suppress the antigen-presenting abilities of microglia. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:177 / 185
页数:9
相关论文
共 41 条
[1]   DIFFERENTIATED RAT GLIAL CELL STRAIN IN TISSUE CULTURE [J].
BENDA, P ;
LIGHTBODY, J ;
SATO, G ;
LEVINE, L ;
SWEET, W .
SCIENCE, 1968, 161 (3839) :370-+
[2]   INFLAMMATORY LEUKOCYTES ASSOCIATED WITH INCREASED IMMUNOSUPPRESSION BY GLIOBLASTOMA [J].
BLACK, KL ;
CHEN, K ;
BECKER, DP ;
MERRILL, JE .
JOURNAL OF NEUROSURGERY, 1992, 77 (01) :120-126
[3]  
BOGDAN C, 1992, J BIOL CHEM, V267, P23301
[4]  
CHAO CC, 1992, J IMMUNOL, V149, P2736
[5]  
CHOUAIB S, 1988, LYMPHOKINE RES, V7, P237
[6]  
DE WMR, 1991, J EXP MED, V174, P1209
[7]  
FIERZ W, 1985, J IMMUNOL, V134, P3785
[8]   IMMUNE-MEDIATED ENCEPHALITIS - ON THE ROLE OF ANTIGEN-PRESENTING CELLS IN BRAIN-TISSUE [J].
FONTANA, A ;
FREI, K ;
BODMER, S ;
HOFER, E .
IMMUNOLOGICAL REVIEWS, 1987, 100 :185-201
[9]   ASTROCYTES PRESENT MYELIN BASIC-PROTEIN TO ENCEPHALITOGENIC T-CELL LINES [J].
FONTANA, A ;
FIERZ, W ;
WEKERLE, H .
NATURE, 1984, 307 (5948) :273-276
[10]  
FONTANA A, 1982, J IMMUNOL, V129, P2413