Antigen-presenting capability of glial cells under glioma-harboring conditions and the effect of glioma-derived factors on antigen presentation

被引：28

作者：

Taniguchi, Y ^{[1
]}

Ono, K ^{[1
]}

Yoshida, S ^{[1
]}

Tanaka, R ^{[1
]}

机构：

[1] Niigata Univ, Brain Res Inst, Dept Neurosurg, Niigata 9518585, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 111卷 / 1-2期

关键词：

microglia; astrocyte; antigen-presenting capability; rat glioma;

D O I：

10.1016/S0165-5728(00)00361-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The antigen-presenting capability of syngeneic rat glial cells was investigated under glioma-harboring conditions. Microglia induced a significant proliferation of glioma-primed splenocytes, but astrocytes did not. Furthermore, astrocytes suppressed the accessory cell function of microglia. The presence of both indomethacin and anti-interleukin (IL)-10 neutralizing antibody during priming of microglia enhanced splenocyte proliferation. The glioma culture supernatants down-regulated the interferon-gamma -induced expression of major histocompatibility complex class LI molecules on microglia. The down-regulation was blocked by indomethacin and anti-IL-10 antibody. The results suggest that microglia but not astrocytes may function as antigen-presenting cells in glioma, and that glioma may suppress the antigen-presenting abilities of microglia. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：177 / 185

页数：9

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