Emerging mechanisms of immune regulation: the extended B7 family and regulatory T cells

被引：19

作者：

Loke, P ^{[1
]}

Allison, JP ^{[1
]}

机构：

[1] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2004年 / 6卷 / 05期

关键词：

antitumor immunity; autoimmunity; costimulation; inflammation; regulatory T cells;

D O I：

10.1186/ar1225

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Whereas B7-1/B7-2 and CD28/cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) serve as the main switches regulating the clonal composition of activated naive T cells, other B7 family members fine-tune the expansion and properties of activated T cells. Inducible costimulatory molecule (ICOS)-B7h promotes T-dependent antibody isotype switching and expansion of effector cells. Effector T cells trafficking into inflamed tissues interact with antigen-presenting cells there and are regulated by PD-1 and its ligands. B7-H3 and B7x could control the interaction between effector T cells and the peripheral tissues. The different varieties of regulatory T cells could regulate both naive T cell activation and effector function through costimulatory receptor/ligands.

引用

页码：208 / 214

页数：7

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