Emerging mechanisms of immune regulation: the extended B7 family and regulatory T cells

被引：19

作者：

Loke, P ^{[1
]}

Allison, JP ^{[1
]}

机构：

[1] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2004年 / 6卷 / 05期

关键词：

antitumor immunity; autoimmunity; costimulation; inflammation; regulatory T cells;

D O I：

10.1186/ar1225

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Whereas B7-1/B7-2 and CD28/cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) serve as the main switches regulating the clonal composition of activated naive T cells, other B7 family members fine-tune the expansion and properties of activated T cells. Inducible costimulatory molecule (ICOS)-B7h promotes T-dependent antibody isotype switching and expansion of effector cells. Effector T cells trafficking into inflamed tissues interact with antigen-presenting cells there and are regulated by PD-1 and its ligands. B7-H3 and B7x could control the interaction between effector T cells and the peripheral tissues. The different varieties of regulatory T cells could regulate both naive T cell activation and effector function through costimulatory receptor/ligands.

引用

页码：208 / 214

页数：7

共 61 条

[21] PD-1 inhibits antiviral immunity at the effector phase in the liver [J].

Iwai, YH ;

Terawaki, S ;

Ikegawa, M ;

Okazaki, T ;

Honjo, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (01) :39-50

[22] Blockade of B7-H1 suppresses intestinal inflammation the development of chronic [J].

Kanai, T ;

Totsuka, T ;

Uraushihara, K ;

Makita, S ;

Nakamura, T ;

Koganei, K ;

Fukushima, T ;

Akiba, H ;

Yagita, H ;

Okumura, K ;

Machida, T ;

Iwai, H ;

Azuma, M ;

Chen, LP ;

Watanabe, M .

JOURNAL OF IMMUNOLOGY, 2003, 171 (08) :4156-4163

[23] Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype [J].

Kemper, C ;

Chan, AC ;

Green, JM ;

Brett, KA ;

Murphy, KM ;

Atkinson, JP .

NATURE, 2003, 421 (6921) :388-392

[24] An essential role for Scurfin in CD4+CD25+ T regulatory cells [J].

Khattri, R ;

Cox, T ;

Yasayko, SA ;

Ramsdell, F .

NATURE IMMUNOLOGY, 2003, 4 (04) :337-342

[25] Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+ T cells [J].

Kuhns, MS ;

Epshteyn, V ;

Sobel, RA ;

Allison, LP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12711-12716

[26] Constitutive expression of the B7h ligand for inducible costimulator on naive B cells is extinguished after activation by distinct B cell receptor and interleukin 4 receptor-mediated pathways and can be rescued by CD40 signaling [J].

Liang, L ;

Porter, EM ;

Sha, WC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (01) :97-108

[27] Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses [J].

Liang, SC ;

Latchman, YE ;

Buhlmann, JE ;

Tomczak, MF ;

Horwitz, BH ;

Freeman, GJ ;

Sharpe, AH .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (10) :2706-2716

[28] B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism [J].

Liu, XL ;

Gao, JX ;

Wen, J ;

Yin, LJ ;

Li, O ;

Zuo, T ;

Gajewski, TF ;

Fu, YX ;

Zheng, P ;

Liu, Y .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (12) :1721-1730

[29] Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10 [J].

Löhning, M ;

Hutloff, A ;

Kallinich, T ;

Mages, HW ;

Bonhagen, K ;

Radbruch, A ;

Hamelmann, E ;

Kroczek, RA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (02) :181-193

[30] PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells [J].

Loke, P ;

Allison, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :5336-5341

← 1 2 3 4 5 6 7 →