Strong differences in the in vitro cytotoxicity of three isomeric dichlorobis(2-phenylazopyridine)ruthenium(II) complexes

被引：168

作者：

Velders, AH

Kooijman, H

Spek, AL

Haasnoot, JG

de Vos, D

Reedijk, J

机构：

[1] Leiden Univ, Gorlaeus Labs, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands

[2] Univ Utrecht, Bijvoet Ctr Biomol Res Crystal & Struct Chem, NL-3584 CH Utrecht, Netherlands

[3] Pharmachem BV, NL-2003 RN Haarlem, Netherlands

来源：

INORGANIC CHEMISTRY | 2000年 / 39卷 / 14期

关键词：

D O I：

10.1021/ic000167t

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The three isomeric dichlororuthenium(II) complexes alpha-, beta-, and gamma-[Ru(azpy)(2)Cl-2] (azpy = 2-phenylazopyridine) have been investigated for their cytotoxic properties against a series of tumor-cell lines. The complex alpha-[Ru(azpy)(2)Cl-2] appears to have a very high cytotoxicity (on the order of magnitude as that of the well-known antitumor complexes cisplatin), which stands in contrast to the much lower cytotoxicity of the trans-dichloro complex gamma-[Ru(azpy)(2)Cl-2] and the cis-dichloro isomer beta-[Ru(azpy)(2)Cl-2]. [GRAPHICS]

引用

页码：2966 / +

页数：3

共 25 条

[1] HYDROXIDE-ASSISTED STEREOSPECIFIC ISOMERIZATION OF A TRANS-DICHLORO BIS CHELATE OF RUTHENIUM(II) [J].