Configuration and enantioselective synthesis of the fungus metabolite WF 14861

被引：5

作者：

Detterbeck, R ^{[1
]}

Hesse, M ^{[1
]}

机构：

[1] Univ Zurich, Inst Organ Chem, CH-8057 Zurich, Switzerland

来源：

HELVETICA CHIMICA ACTA | 2003年 / 86卷 / 01期

关键词：

D O I：

10.1002/hlca.200390015

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A short enantioselective synthesis of the cathepsine inhibitor WF14861 (1) from the funghi Colletotrichum sp. as well as of its diasteroisomer 21 is presented. Comparison of the NMR data of the final products and, in particular, of the [alpha](D) values of the intermediates allowed the confirmation of the formerly proposed structure 1. In addition, the so far unknown absolute configuration of all three stereogenic centres of WF14861 could be established by this synthesis.

引用

页码：222 / 232

页数：11

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