Activated protein C resistance (FVLeiden) and thrombosis:: factor V mutations causing hypercoagulable states

被引：24

作者：

Nicolaes, GAF

Dahlbäck, B

机构：

[1] Lund Univ, Div Clin Chem, Dept Lab Med, Wallenberg Lab,Univ Hosp Malmo, S-20502 Malmo, Sweden

[2] Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Biochem, NL-6200 MD Maastricht, Netherlands

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2003年 / 17卷 / 01期

关键词：

D O I：

10.1016/S0889-8588(02)00097-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The integrity of the vascular system is of prime importance for survival. Therefore, several emergency and repair systems safeguard the circulatory system. Multiple processes jointly limit vascular damage and blood loss. In this article, the authors focus on the protein C anticoagulant pathway and the role of activated protein C resistance in thrombotic disease, and they discuss the involvement in thrombosis of mutations other than the Arg506Gln mutation in the gene encoding for factor V.

引用

页码：37 / +

页数：26

共 157 条

[71] The factor V R2 allele: Risk of venous thromboembolism, factor V levels and resistance to activated protein C [J].