Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland

被引：157

作者：

Misra, RR

Ratnasinghe, D

Tangrea, JA

Virtamo, J

Andersen, MR

Barrett, M

Taylor, PR

Albanes, D

机构：

[1] NCI, Canc Prevent Studies Branch, Ctr Canc Res, Bethesda, MD 20892 USA

[2] New Chem Ent Inc, Thetagen Div, Bothell, WA USA

[3] Informat Management Serv Inc, Silver Spring, MD 20904 USA

[4] Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, FIN-00300 Helsinki, Finland

[5] NCI, Nutrit Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

来源：

CANCER LETTERS | 2003年 / 191卷 / 02期

关键词：

alpha-tocopherol; beta-carotene; lung cancer; DNA repair; smoking;

D O I：

10.1016/S0304-3835(02)00638-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Associations between lung cancer risk and common polymorphisms in the DNA repair genes xeroderma pigmentosum complementation group D (XPD), X-ray repair cross-complementing group 1 (XRCC1), XRCC3 and apurinic/apyrimidinic endonuclease/redox factor 1 were examined within a randomized clinical trial designed to determine whether alpha-tocopherol, beta-carotene, or both would reduce cancer incidence among male smokers in Finland. We found no direct association between lung cancer risk and any of the DNA repair genotypes studied, however, the association between XPD codon 751 genotype and lung cancer was modified by alpha-tocopherol supplementation, and the association between XRCC1 codon 399 genotype and lung cancer was modified by the amount of smoking. Our results suggest that common alterations in single DNA repair genes are not major determinants of lung cancer susceptibility among smokers. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：171 / 178

页数：8

共 23 条

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