The future of bacteriophage biology

被引：123

作者：

Campbell, A ^{[1
]}

机构：

[1] Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

来源：

NATURE REVIEWS GENETICS | 2003年 / 4卷 / 06期

关键词：

D O I：

10.1038/nrg1089

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

After an illustrious history as one of the primary tools that established the foundations of molecular biology, bacteriophage research is now undergoing a renaissance in which the primary focus is on the phages themselves rather than the molecular mechanisms that they explain. Studies of the evolution of phages and their role in natural ecosystems are flourishing. Practical questions, such as how to use phages to combat human diseases that are caused by bacteria, how to eradicate phage pests in the food industry and what role they have in the causation of human diseases, are receiving increased attention. Phages are also useful in the deeper exploration of basic molecular and biophysical questions.

引用

收藏

页码：471 / 477

页数：7

相关论文

共 59 条

[31] Broad-range bacteriophage resistance in Streptococcus thermophilus by insertional mutagenesis [J].

Lucchini, S ;

Sidoti, J ;

Brüssow, H .

VIROLOGY, 2000, 275 (02) :267-277

[32] A bipartite bacteriophage T4 SOC and HOC randomized peptide display library:: Detection and analysis of phage T4 terminase (gp17) and late σ factor (gp55) interaction [J].

Malys, N ;

Chang, DY ;

Baumann, RG ;

Xie, DM ;

Black, LW .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 319 (02) :289-304

[33] Long-circulating bacteriophage as antibacterial agents [J].

Merril, CR ;

Biswas, B ;

Carlton, R ;

Jensen, NC ;

Creed, GJ ;

Zullo, S ;

Adhya, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (08) :3188-3192

[34] No syringes please, ejection of phage T7 DNA from the virion is enzyme driven [J].

Molineux, IJ .

MOLECULAR MICROBIOLOGY, 2001, 40 (01) :1-8

[35] Detecting alien genes in bacterial genomes [J].

Mrázek, J ;

Karlin, S .

MOLECULAR STRATEGIES IN BIOLOGICAL EVOLUTION, 1999, 870 :314-329

[36] SITE-SPECIFIC RECOMBINATION INTERMEDIATES TRAPPED WITH SUICIDE SUBSTRATES [J].

NUNESDUBY, SE ;

MATSUMOTO, L ;

LANDY, A .

CELL, 1987, 50 (05) :779-788

[37] SWAPPING DNA STRANDS AND SENSING HOMOLOGY WITHOUT BRANCH MIGRATION IN LAMBDA-SITE-SPECIFIC RECOMBINATION [J].

NUNESDUBY, SE ;

AZARO, MA ;

LANDY, A .

CURRENT BIOLOGY, 1995, 5 (02) :139-148

[38] Sequence of Shiga toxin 2 phage 933W from Escherichia coli O157:H7:: Shiga toxin as a phage late-gene product [J].

Plunkett, G ;

Rose, DJ ;

Durfee, TJ ;

Blattner, FR .

JOURNAL OF BACTERIOLOGY, 1999, 181 (06) :1767-1778

[39]

Ptashne M., 2002, GENES SIGNALS

[40]

Ptashne M., 1992, A Genetic Switch: Phage lambda and Higher Organisms

← 1 2 3 4 5 6 →