The promise of minocycline in neurology

被引：435

作者：

Yong, VW

Wells, J

Giuliani, F

Casha, S

Power, C

Metz, LM

机构：

[1] Univ Calgary, Dept Oncol, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Dept Clin Neurosci, Calgary, AB T2N 4N1, Canada

[3] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada

来源：

LANCET NEUROLOGY | 2004年 / 3卷 / 12期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1016/S1474-4422(04)00937-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The capacity of minocycline to alleviate disease for several neurological disorders in animals is increasingly being recognised. Indeed, that one drug alone can attenuate the severity of disease in stroke, multiple sclerosis, spinal-cord injury, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis is astounding. In this review, we describe the evidence for the efficacy of minocycline in several animal models of neurological disease, discuss the mechanisms by which minocycline affects a range of neurological diseases with diverse causes, and introduce the emerging investigation of minocycline in clinical neurology. The encouraging results of minocycline in experimental neurology bode well for its therapeutic use in human neurological diseases.

引用

收藏

页码：744 / 751

页数：8

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