TNF receptor 2 pathway: drug target for autoimmune diseases

被引：401

作者：

Faustman, Denise ^{[1
]}

Davis, Miriam

机构：

[1] Massachusetts Gen Hosp, Immunobiol Lab, Charlestown, MA 02129 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2010年 / 9卷 / 06期

关键词：

TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; SYSTEMIC-LUPUS-ERYTHEMATOSUS; NONOBESE DIABETIC MICE; MONOCLONAL-ANTIBODY HOKT3-GAMMA-1(ALA-ALA); MAJOR HISTOCOMPATIBILITY COMPLEX; INFLAMMATORY-BOWEL-DISEASE; ALPHA-INDUCED APOPTOSIS; SIGNALS CELL-DEATH; CD8+ T-CELLS;

D O I：

10.1038/nrd3030

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Although drug development has advanced for autoimmune diseases, many current therapies are hampered by adverse effects and the frequent destruction or inactivation of healthy cells in addition to pathological cells. Targeted autoimmune therapies capable of eradicating the rare autoreactive immune cells that are responsible for the attack on the body's own cells are yet to be identified. This Review presents a new emerging approach aimed at selectively destroying autoreactive immune cells by specific activation of tumour necrosis factor receptor 2 (TNFR2), which is found on autoreactive and normal T lymphocytes, with the potential of avoiding or reducing the toxicity observed with existing therapies.

引用

页码：482 / 493

页数：12

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