Regulation of dendritic growth by calcium and neurotrophin signaling

被引：45

作者：

Dijkhuizen, PA ^{[1
]}

Ghosh, A ^{[1
]}

机构：

[1] UCSD, Div Biol, La Jolla, CA 92093 USA

来源：

DEVELOPMENT, DYNAMICS AND PATHOLOGY OF NEURONAL NETWORKS: FROM MOLECULES TO FUNCTIONAL CIRCUITS | 2005年 / 147卷

关键词：

D O I：

10.1016/S0079-6123(04)47002-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The development of cortical dendrites is regulated by both activity-dependent and activity-independent signaling. Activity-dependent dendritic growth involves calcium-dependent gene expression. Both CREB and CREST are transactivators that contribute to calcium-dependent dendritic growth. Dendritic development is also regulated by extracellular factors such as neurotrophins. Neurotrophin-dependent dendritic growth is mediated by the MAP kinase and PI 3-kinase pathways. Selective responsiveness to activity cues and neurotrophins may contribute to morphological diversity in the nervous system.

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页码：17 / 27

页数：11

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