The cross-regulation between SOX15 and Wnt signaling pathway

被引：35

作者：

Moradi, Ali ^{[1
]}

Ghasemi, Faezeh ^{[2
,3
]}

Anvari, Kazem ^{[4
]}

Hassanian, Seyed Mahdi ^{[5
,6
]}

Simab, Saeideh Ahmadi ^{[4
]}

Ebrahimi, Safieh ^{[6
]}

Hesari, Amirreza ^{[1
,2
]}

Forghanifard, Mohammad Mahdi ^{[1
]}

Boroushaki, Mohammad Taher ^{[7
,8
]}

ShahidSales, Soodabeh ^{[4
]}

Avan, Amir ^{[5
]}

机构：

[1] Islamic Azad Univ, Damghan Branch, Dept Biol, Damghan, Iran

[2] Mashhad Univ Med Sci, Mol Med Grp, Sch Med, Dept Modern Sci & Technol, Mashhad, Iran

[3] Arak Univ Med Sci, Fac Med, Dept Biotechnol, Arak, Iran

[4] Mashhad Univ Med Sci, Sch Med, Canc Res Ctr, Mashhad, Iran

[5] Mashhad Univ Med Sci, Sch Med, Metab Syndrome Res Ctr, Mashhad, Iran

[6] Mashhad Univ Med Sci, Sch Med, Dept Med Biochem, Mashhad, Iran

[7] Mashhad Univ Med Sci, Fac Med, Dept Pharmacol, Mashhad, Iran

[8] Mashhad Univ Med Sci, Fac Med, Pharmacol Res Ctr Med Plants, Mashhad, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2017年 / 232卷 / 12期

关键词：

biomarker; cancer; Sox15; WNT; B-CATENIN pathway; BETA-CATENIN; CANCER; EXPRESSION; GENES; OVEREXPRESSION; PROLIFERATION; PROGNOSIS; CELLS;

D O I：

10.1002/jcp.25802

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

WNT/B-CATENIN signaling pathway is one of the key dysregulated pathways in different tumor types, which regulate the expression of several genes involved in cell proliferation, differentiation, and survival. This pathway is being modulated by sex-determining region Y-box (SOX) family genes. The functions of these genes are suggested as tumor suppressor or oncogene. SOX genes transcribe a group of transcription factors that play important roles in embryonic development and carcinogenesis. Among them, SOX15 is recently been identified as a novel tumor suppressor in pancreatic and esophagus cancers with a potential role in modulating Wnt/b-catenin signaling. This report summarizes the current knowledge about Wnt/b-catenin signaling pathway and its cross talk with SOX15 with particular emphasis on the value of SOX gene expression as prognostic or predictive biomarker in cancer.

引用

页码：3221 / 3225

页数：5

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