Multiple Sclerosis and the Accumulation of Iron in the Basal Ganglia: Quantitative Assessment of Brain Iron Using MRI T2 Relaxometry

被引：48

作者：

Burgetova, A. ^{[1
]}

Seidl, Z. ^{[1
,3
]}

Krasensky, J. ^{[1
]}

Horakova, D. ^{[2
]}

Vaneckova, M. ^{[1
]}

机构：

[1] Charles Univ Prague, Gen Teaching Hosp, Fac Med 1, Dept Radiol, CZ-12808 Prague 2, Czech Republic

[2] Charles Univ Prague, Gen Teaching Hosp, Fac Med 1, Dept Neurol, CZ-12808 Prague 2, Czech Republic

[3] Coll Med, Prague, Czech Republic

来源：

EUROPEAN NEUROLOGY | 2010年 / 63卷 / 03期

关键词：

Multiple sclerosis; Iron accumulation; Magnetic resonance imaging; T-2; relaxometry; MATTER T2 HYPOINTENSITY; GRAY-MATTER; ATROPHY; AGE; NEURODEGENERATION; INHIBITION; METABOLISM; SIGNAL;

D O I：

10.1159/000279305

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this work was to quantify the accumulation of iron in the basal ganglia in multiple sclerosis (MS) patients and in a control group, and to investigate the relationship between iron accumulation and other parameters assessed in MS, i.e. lesion load (LL) and brain parenchymal fraction (BPF). Magnetic resonance imaging T-2 relaxometry was used for the measurement. 970 patients with clinically definite MS and 117 controls were examined. Patients were divided into three subgroups according to LL and BPF. This work provides quantitative evidence of increased iron accumulation in the basal ganglia in MS patients in comparison to healthy controls. We also found that in the subgroup with small LL value, iron accumulation is higher than in the subgroup with large LL value. The hypothesis of a neurodegenerative component of MS is supported by the changes in iron content in the brain. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：136 / 143

页数：8

共 36 条

[31] AGE DISTRIBUTION AND IRON DEPENDENCY OF THE T2-RELAXATION TIME IN THE GLOBUS-PALLIDUS AND PUTAMEN [J].