Cyclic hydropyran oligolides as preorganized ligand arrays: Modular assembly of 18-, 24-, 36-, 48-, 54- and 72-membered rings via iteration and cyclooligomerization

被引：13

作者：

Burke, SD ^{[1
]}

Heap, CR ^{[1
]}

Porter, WJ ^{[1
]}

Song, YT ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES DIV,ANN ARBOR,MI 48105

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 03期

关键词：

D O I：

10.1016/0040-4039(95)02168-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Modular assembly routes to cyclic hydropyran oligolides of diverse structures are described. Macrolactonization of the appropriate tris(hydropyran) hydroxy acid provided compounds 1-8, whereas macrocycles 9-13 resulted from the cyclodimerization, cyclotrimerization, and cyclotetramerization of the bis- or tris(hydropyran) seco acids, utilizing the ''normal'' or ''modified'' Yamaguchi lactonization conditions.

引用

页码：343 / 346

页数：4

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