Cancer preventive mechanisms of the green tea polyphenol (-)-epigallocatechin-3-gallate

被引：90

作者：

Chen, Lei

Zhang, Hong-Yu ^{[1
]}

机构：

[1] Shandong Univ, Shandong Prov Res Ctr Bioinformat Engn & Tech, Ctr Adv Study, Zibo 255049, Peoples R China

[2] Shandong Normal Univ, Coll Life Sci, Jinan 250014, Peoples R China

来源：

MOLECULES | 2007年 / 12卷 / 05期

关键词：

green tea; (-)-epigallocatechin gallate; cancer prevention; mechanisms;

D O I：

10.3390/12050946

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accumulating evidence indicates that consumption of tea, especially green tea, is good for preventing cancer. To elucidate the cancer preventive mechanisms of green tea, much effort has been devoted to investigating the anticancer effects of (-)-epigallocatechin-3-gallate (EGCG), the major component of green tea. It has been revealed that EGCG restrained carcinogenesis in a variety of tissues through inhibition of mitogen-activated protein kinases (MAPK), growth factor-related cell signaling, activation of activator protein 1 (AP-1) and nuclear factor-B (NF-kappa B), topoisomerase I, matrix metalloproteinases and other potential targets. Therefore, EGCG is a multipotent anticancer agent, which not only provides solid evidence to support the anticancer potential of green tea, but also offers new clues for discovering multiple-targeted anticancer drugs.

引用

页码：946 / 957

页数：12

共 61 条

[41] RETRACTED: Epigallocatechin-3-gallate inhibits photocarcinogenesis through inhibition of anglogenic factors and activation of CD8+ T cells in tumors (Retracted article. See vol. 94, pg. 618, 2018) [J].