Transglutaminase function in epidermis

被引：161

作者：

Eckert, RL

Sturniolo, MT

Broome, AM

Ruse, M

Rorke, EA

机构：

[1] Case Sch Med, Dept Physiol & Biophys, Cleveland, OH 44106 USA

[2] Case Sch Med, Dept Oncol, Cleveland, OH 44106 USA

[3] Case Sch Med, Dept Dermatol, Cleveland, OH 44106 USA

[4] Case Sch Med, Dept Biochem, Cleveland, OH 44106 USA

[5] Case Sch Med, Dept Environm Hlth Sci, Cleveland, OH 44106 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2005年 / 124卷 / 03期

关键词：

calcium; differentiation; epidermis; involucrin; keratinocyte; transglutaminase;

D O I：

10.1111/j.0022-202X.2005.23627.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Surface epithelial cells, such as the epidermal keratinocyte, undergo a process of terminal cell differentiation that results in the construction of a multilayered epithelium. This epithelium functions to protect the organism from the environment. Transglutaminases, enzymes that catalyze the formation of isopeptide protein-protein cross-links, are key enzymes involved in the construction of this structure. This brief review will focus on the role of these enzymes in constructing the epidermal surface.

引用

收藏

页码：481 / 492

页数：12

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