Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse

被引：62

作者：

Kurose, H ^{[1
]}

Bito, T ^{[1
]}

Adachi, T ^{[1
]}

Shimizu, M ^{[1
]}

Noji, S ^{[1
]}

Ohuchi, H ^{[1
]}

机构：

[1] Univ Tokushima, Fac Engn, Dept Biol Sci & Technol, Tokushima 7708506, Japan

来源：

GENE EXPRESSION PATTERNS | 2004年 / 4卷 / 06期

关键词：

fibroblast growth factor; FGF19; FGF15; eye development; embryogenesis; retina; retinal horizontal cell; cranial placodes; lens; chicken; mouse;

D O I：

10.1016/j.modgep.2004.04.005

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The normal development of eyes relies on proper signaling through Fibroblast growth factor (FGF) receptors, but the source and identity of cognate ligands have remained largely unknown. We have found that Fgf19 is expressed in the developing chicken retina. In situ hybridization discloses dynamic expression patterns for Fgf19 in the optic vesicle, lens primordia and retinal horizontal cells. Overall expression pattern of Fgf19 during chicken embryogenesis was also examined: Fgf19 is expressed in the regions associated with cranial placodes induction, boundary regions of rhombomeres, somites, specific groups of neural cells in midbrain, hindbrain, and those derived from epibranchial placodes, and the apical ectodermal ridge of limb buds. Expression pattern of the Fgf19-orthologous gene Fgf15 was further examined in the mouse developing eye. Fgf15 is expressed in the optic vesicle, a subset of progenitor cells of neural retina, and emerging ganglion and amacrine cells during retinogenesis. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：687 / 693

页数：7

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