Common γ chain cytokines:: Dissidence in the details

被引：48

作者：

Alves, Nuno L. ^{[1
]}

Arosa, Fernando A.

van Lier, Rene A. W.

机构：

[1] Acad Med Ctr, Dept Expt Immunol, Amsterdam, Netherlands

[2] Univ Porto, IBMC, P-4100 Oporto, Portugal

来源：

IMMUNOLOGY LETTERS | 2007年 / 108卷 / 02期

关键词：

homeostasis; CD8 T cells; gamma(c) cytokines; CD8; T-CELLS; BASAL HOMEOSTATIC PROLIFERATION; THYMIC STROMAL LYMPHOPOIETIN; IL-7; RECEPTOR; CUTTING EDGE; HUMAN NAIVE; SELECTIVE STIMULATION; LYMPHOID DEVELOPMENT; NATURAL-KILLER; DEFICIENT MICE;

D O I：

10.1016/j.imlet.2006.11.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokines of the common cytokine-receptor gamma-chain (gamma(c)) family are essential for the development and maintenance of lymphocytes. Herein, we will focus on the roles of interleukin-2 (IL-2), IL-7, IL-15 and IL-21, in the orchestration of CD8 T cell responses. Among these cytokines, IL-7 has emerged as a master regulator of survival of immature and mature T lymphocytes, while IL-2, IL-15 and IL-21 appear to have specific functions in T cell homeostasis and differentiation. Hence, the gamma(c) has evolved as an elegant anchor through which related cytokines regulate distinct biological responses in T cells. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：113 / 120

页数：8

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