Organizing the cell cortex: the role of ERM proteins

被引：817

作者：

Fehon, Richard G. ^{[1
]}

McClatchey, Andrea I. ^{[2
,3
]}

Bretscher, Anthony ^{[4
]}

机构：

[1] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA

[2] Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA

[3] Harvard Univ, Sch Med, Dept Pathol, Charlestown, MA 02129 USA

[4] Cornell Univ, Weill Inst Cell & Mol Biol, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2010年 / 11卷 / 04期

基金：

美国国家卫生研究院;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; CORTICAL ACTIN ORGANIZATION; MESSENGER-RNA LOCALIZATION; MOESIN-DEFICIENT MICE; RADIXIN FERM DOMAIN; N-TERMINAL DOMAIN; STRUCTURAL BASIS; EZRIN/RADIXIN/MOESIN PROTEINS; TUMOR-SUPPRESSOR; BINDING-SITE;

D O I：

10.1038/nrm2866

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Specialized membrane domains are an important feature of almost all cells. In particular, they are essential to tissues that have a highly organized cell cortex, such as the intestinal brush border epithelium. The ERM proteins (ezrin, radixin and moesin) have a crucial role in organizing membrane domains through their ability to interact with transmembrane proteins and the cytoskeleton. In doing so, they can provide structural links to strengthen the cell cortex and regulate the activities of signal transduction pathways. Recent studies examining the structure and in vivo functions of ERMs have greatly advanced our understanding of the importance of membrane-cytoskeleton interactions.

引用

页码：276 / 287

页数：12

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