The role of integrin antagonists in the treatment of inflammatory bowel disease

被引：11

作者：

Beniwal-Patel, Poonam ^{[1
]}

Saha, Sumona ^{[1
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53705 USA

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2014年 / 14卷 / 12期

关键词：

Crohn's disease; immunomodulator; inflammation; integrin; natalizumab; ulcerative colitis; vedolizumab; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; HUMANIZED MONOCLONAL-ANTIBODY; GUT-HOMING INTEGRIN; ADHESION MOLECULES; CROHNS-DISEASE; MAINTENANCE THERAPY; ULCERATIVE-COLITIS; T-CELLS; NATALIZUMAB; EXPRESSION;

D O I：

10.1517/14712598.2014.967209

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Introduction: Ulcerative colitis (UC) and Crohn's disease are chronic inflammatory diseases of the bowel associated with complex inflammatory cascades within the mucosal lining of the gut. Areas covered: INTEGRINS and their use as therapies in UC and Crohn's. Expert Opinion: The anti-adhesion molecules are a welcome addition to the armamentarium of medical therapies for inflammatory bowel disease.

引用

页码：1815 / 1823

页数：9

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