Analysis of diversity of mutations in the mecI gene and mecA promoter/operator region of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis

被引：31

作者：

Kobayashi, N ^{[1
]}

Taniguchi, K ^{[1
]}

Urasawa, S ^{[1
]}

机构：

[1] Sapporo Med Univ, Sch Med, Dept Hyg, Chuo Ku, Sapporo, Hokkaido 060, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 03期

关键词：

D O I：

10.1128/AAC.42.3.717

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genomic diversity of mutation in the mecI gene or mecA promoter/operator region was analyzed for clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE). In most MRSA strains, a single base substitution was detected in either the mecI (three different positions) or the mecA promoter (two different positions), while a 28-base deletion in mecI was found in one strain. In contrast, no mutation was detected in these gene sequences of MRSE strains.

引用

页码：717 / 720

页数：4

共 28 条

[1] DISSEMINATION AMONG STAPHYLOCOCCI OF DNA-SEQUENCES ASSOCIATED WITH METHICILLIN RESISTANCE
ARCHER, GL
NIEMEYER, DM
THANASSI, JA
PUCCI, MJ
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (03) : 447 - 454
[2] Archer Gordon L., 1994, Trends in Microbiology, V2, P343, DOI 10.1016/0966-842X(94)90608-4
[3] Ubiquitous presence of a mecA homologue in natural isolates of Staphylococcus sciuri
Couto, I
deLencastre, H
Severina, E
Kloos, W
Webster, JA
Hubner, RJ
Sanches, IS
Tomasz, A
[J]. MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE, 1996, 2 (04): : 377 - 391
[4] LOW-AFFINITY PENICILLIN-BINDING PROTEIN ASSOCIATED WITH BETA-LACTAM RESISTANCE IN STAPHYLOCOCCUS-AUREUS
HARTMAN, BJ
TOMASZ, A
[J]. JOURNAL OF BACTERIOLOGY, 1984, 158 (02) : 513 - 516
[5] MOLECULAR-CLONING AND NUCLEOTIDE-SEQUENCE DETERMINATION OF THE REGULATOR REGION OF MECA GENE IN METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS (MRSA)
HIRAMATSU, K
ASADA, K
SUZUKI, E
OKONOGI, K
YOKOTA, T
[J]. FEBS LETTERS, 1992, 298 (2-3) : 133 - 136
[6] MOLECULAR EVOLUTION OF MRSA
HIRAMATSU, K
[J]. MICROBIOLOGY AND IMMUNOLOGY, 1995, 39 (08) : 531 - 543
[7] SURVEY OF THE METHICILLIN RESISTANCE-ASSOCIATED GENES MECA, MECR1-MECI, AND FEMA-FEMB IN CLINICAL ISOLATES OF METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS
HURLIMANNDALEL, RL
RYFFEL, C
KAYSER, FH
BERGERBACHI, B
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (12) : 2617 - 2621
[8] CLONING AND NUCLEOTIDE-SEQUENCE OF THE PENICILLINASE ANTIREPRESSOR GENE PENJ OF BACILLUS-LICHENIFORMIS
IMANAKA, T
HIMENO, T
AIBA, S
[J]. JOURNAL OF BACTERIOLOGY, 1987, 169 (09) : 3867 - 3872
[9] Ito, 1996, J INFECT CHEMOTHER, V2, P117, DOI [DOI 10.1007/BF02351563, 10.1007/BF02351563]
[10] DETECTION OF MECA, FEMA, AND FEMB GENES IN CLINICAL STRAINS OF STAPHYLOCOCCI USING POLYMERASE CHAIN-REACTION
KOBAYASHI, N
WU, H
KOJIMA, K
TANIGUCHI, K
URASAWA, S
UEHARA, N
OMIZU, Y
KISHI, Y
YAGIHASHI, A
KUROKAWA, I
[J]. EPIDEMIOLOGY AND INFECTION, 1994, 113 (02) : 259 - 266

← 1 2 3 →