Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice

被引：265

作者：

Chan, JY

Kwong, M

Lu, RH

Chang, J

Wang, B

Yen, TSB

Kan, YW ^{[1
]}

机构：

[1] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94121 USA

[3] VA Med Ctr, San Francisco, CA 94121 USA

[4] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

来源：

EMBO JOURNAL | 1998年 / 17卷 / 06期

关键词：

anemia; bZIP gene; knockout mouse; Nrf-1;

D O I：

10.1093/emboj/17.6.1779

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The CNC-basic leucine zipper (CNC-bZIP) family is a subfamily of bZIP proteins identified from independent searches for factors that bind the AP-1-like cis-elements in the beta-globin locus control region, Three members, p45-Nf-e2, Nrf-1 and Nrf-2 have been identified in mammals. Expression of p45-Nf-e2 is largely restricted to hematopoietic cells while Nrf-1 and Nrf-2 are expressed in a wide range of tissues, To determine the function of Nrf-1, targeted disruption of the Nrf-1 gene was carried out. Homozygous Nrf-1 mutant mice are anemic due to a non-cell autonomous defect in definitive erythropoiesis and die in utero.

引用

页码：1779 / 1787

页数：9

共 38 条

[1]

ERYTHROID TRANSCRIPTION FACTOR NF-E2 IS A HEMATOPOIETIC-SPECIFIC BASIC LEUCINE ZIPPER PROTEIN [J].