Autophagy and the degradation of mitochondria

被引：131

作者：

Goldman, Scott J. ^{[1
]}

Taylor, Robert ^{[1
]}

Zhang, Yong ^{[1
]}

Jin, Shengkan ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA

来源：

MITOCHONDRION | 2010年 / 10卷 / 04期

关键词：

Mitophagy; Autophagy; Mitochondria; Adipocyte; Reticulocyte; INDUCED CELLULAR AUTOPHAGY; SACCHAROMYCES-CEREVISIAE; PERMEABILITY TRANSITION; RETICULOCYTE MATURATION; PARKINSONS-DISEASE; ERYTHROID-CELLS; RAT HEPATOCYTES; NERVOUS-SYSTEM; MITOPHAGY; YEAST;

D O I：

10.1016/j.mito.2010.01.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cellular process of macromolecular degradation known as macroautophagy has long been known to play a role in the elimination of mitochondria. Over the past decade, much progress has been made in the development of systems by which the nature and mechanism of mitochondria degradation may be studied. Recent findings imply that the degradation of mitochondria via autophagy may be more specific and more tightly regulated than originally thought, and have led to designation of this specific type of autophagy as "mitophagy". In this review we provide a brief history of the development of mitophagy models and their associated discoveries. (C) 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：309 / 315

页数：7

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