Solid-phase synthesis of cyclic peptide-DNA hybrids

被引：16

作者：

Bleczinski, CF ^{[1
]}

Richert, C ^{[1
]}

机构：

[1] Tufts Univ, Dept Chem, Medford, MA 02155 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 12期

关键词：

D O I：

10.1021/ol000059a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A methodology for preparing cyclic peptide-DNA hybrids on controlled pore glass in high yield is reported. This methodology employs Fmoc/Alloc-protected amino acid and nucleoside phosphoramidites on an omega-hydroxylauric acid-derivatized support and is suitable for library synthesis. A cyclic hybrid of the sequence Glu-Leu-T*T-DP-Lys, where Glu and Lys are linked and T* denotes a 5'-amino-5'-deoxynucleotide, exhibited high resistance to exo- and endonucleases.

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页码：1697 / 1700

页数：4

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