Neurosteroids act on the GABAA receptor at sites on the N-terminal side of the middle of TM2

被引：44

作者：

Rick, CE

Ye, Q

Finn, SE

Harrison, NL

机构：

[1] Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Pharmacol & Physiol Sci, Whitman Labs, Chicago, IL 60637 USA

来源：

NEUROREPORT | 1998年 / 9卷 / 03期

关键词：

alphaxalone; anesthetics; GABA(A) receptor; glycine receptor; mutagenesis; neurosteroids;

D O I：

10.1097/00001756-199802160-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Two sets of chimeras between alphaxalone-sensitive GABA(A) receptor alpha(2) or beta(1) subunits and the alphaxalone-insensitive glycine receptor alpha(1) subunit were constructed to determine the structural domains important for the modulatory actions of neuroactive steroids. These data suggest that the site of action for neurosteroids on GABA(A) receptors is not the same as that for volatile anesthetics and ethanol, but is on the N-terminal side of the middle of TM2. (C) 1998 Rapid Science Ltd.

引用

页码：379 / 383

页数：5

共 22 条

[1] The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid [J].