Rituximab and concomitant leflunomide for the treatment of rheumatoid arthritis

被引：10

作者：

Henes, Joerg Christoph ^{[1
]}

Schedel, Joerg ^{[1
]}

Kanz, Lothar ^{[1
]}

Koetter, Ina ^{[1
]}

机构：

[1] Univ Tubingen Hosp, Dept Internal Med Oncol Haematol Immunol Rheumato, D-72076 Tubingen, Germany

来源：

RHEUMATOLOGY INTERNATIONAL | 2010年 / 30卷 / 05期

关键词：

Rheumatoid arthritis; Rituximab; Leflunomide; DOUBLE-BLIND; EFFICACY; SAFETY; METHOTREXATE; CRITERIA; THERAPY; TRIAL;

D O I：

10.1007/s00296-009-1302-z

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Rituximab has only been approved in combination with methotrexate for the treatment of rheumatoid arthritis. As some patients have intolerance to methotrexate, alternative co-therapies are needed. This method involved retrospective analysis of ten patients treated with a combination of rituximab and leflunomide. Primary outcome measures were the DAS28 response at month 6 and the time to relapse. The median initial DAS 28 of 5.7 (3.2-7.2) was reduced to 3.5 (1.9-6.1) at month 6. 70% of the patients achieved a good or moderate response, whereas 30% showed no response. Two patients had to stop leflunomide due to adverse effects. Two patients had to reduce the leflunomide dose to 10 mg/day. 5/8 patients experienced a relapse after a median of 10 (6-30) months and were successfully re-treated with rituximab. This small case series suggests that leflunomide might offer an alternative DMARD combination option for the treatment of RA with rituximab.

引用

页码：709 / 712

页数：4

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