International network of cancer genome projects

被引：1658

作者：

Hudson, Thomas J. ^{[2
]}

Anderson, Warwick ^{[2
]}

Aretz, Axel ^{[3
]}

Barker, Anna D. ^{[4
]}

Bell, Cindy ^{[5
]}

Bernabe, Rosa R. ^{[6
]}

Bhan, M. K. ^{[7
]}

Calvo, Fabien ^{[8
]}

Eerola, Iiro ^{[9
]}

Gerhard, Daniela S. ^{[4
]}

Guttmacher, Alan ^{[10
]}

Guyer, Mark ^{[11
]}

Hemsley, Fiona M. ^{[12
]}

Jennings, Jennifer L. ^{[1
]}

Kerr, David ^{[13
]}

Klatt, Peter ^{[6
]}

Kolar, Patrik ^{[9
]}

Kusuda, Jun ^{[14
]}

Lane, David P. ^{[12
]}

Laplace, Frank ^{[15
]}

Lu, Youyong ^{[16
]}

Nettekoven, Gerd ^{[17
]}

Ozenberger, Brad ^{[11
]}

Peterson, Jane ^{[11
]}

Rao, T. S. ^{[7
]}

Remacle, Jacques ^{[9
]}

Schafer, Alan J. ^{[18
]}

Shibata, Tatsuhiro ^{[19
]}

Stratton, Michael R. ^{[20
]}

Vockley, Joseph G. ^{[4
]}

Watanabe, Koichi ^{[21
]}

Yang, Huanming ^{[22
]}

Yuen, Matthew M. F. ^{[23
]}

Knoppers, M. ^{[24
,25
]}

Bobrow, Martin ^{[26
]}

Cambon-Thomsen, Anne ^{[27
]}

Dressler, Lynn G. ^{[28
]}

Dyke, Stephanie O. M. ^{[20
]}

Joly, Yann ^{[24
]}

Kato, Kazuto ^{[29
]}

Kennedy, Karen L. ^{[20
]}

Nicolas, Pilar ^{[30
]}

Parker, Michael J. ^{[31
]}

Rial-Sebbag, Emmanuelle ^{[27
]}

Romeo-Casabona, Carlos M. ^{[30
]}

Shaw, Kenna M. ^{[4
]}

Wallace, Susan ^{[24
,25
]}

Wiesner, Georgia L. ^{[32
,33
]}

Zeps, Nikolajs ^{[34
]}

Lichter, Peter ^{[35
]}

机构：

[1] Ontario Inst Canc Res, Toronto, ON M5G 0A3, Canada

[2] Natl Hlth & Med Res Council, Canberra, ACT 2601, Australia

[3] German Aerosp Ctr DLR, Project Management Agcy, D-53175 Bonn, Germany

[4] NCI, US Natl Inst Hlth, Bethesda, MD 20892 USA

[5] Genome Canada, Ottawa, ON K2P 1P1, Canada

[6] Minist Sci & Innovat, Secretariat State Res, Madrid 28027, Spain

[7] Govt India, Minist Sci & Technol, Dept Biotechnol, New Delhi 110003, India

[8] Natl Canc Inst, F-92513 Boulogne, France

[9] European Commiss, Hlth Res Directorate, Genom & Syst Biol Unit, B-1049 Brussels, Belgium

[10] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, US Natl Inst Hlth, Bethesda, MD 20892 USA

[11] NHGRI, US Natl Inst Hlth, Bethesda, MD 20892 USA

[12] Canc Res UK, London WC2A 3PX, England

[13] Qatar Fdn, Sidra Med & Res Ctr, Doha, Qatar

[14] Natl Inst Biomed Innovat, Osaka 5670085, Japan

[15] Fed Minist Educ & Res, Div Mol Life Sci, D-11055 Berlin, Germany

[16] Peking Univ, Sch Oncol, Beijing Canc Inst & Hosp, Beijing 100142, Peoples R China

[17] German Canc Aid, D-53113 Bonn, Germany

[18] Wellcome Trust Res Labs, London NW1 2BE, England

[19] Natl Canc Ctr, Chuo Ku, Tokyo 1040045, Japan

[20] Hinxton, Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[21] RIKEN, Yokohama Inst, Kanagawa, Japan

[22] BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China

[23] Hong Kong Univ Sci & Technol, Hong Kong, Hong Kong, Peoples R China

[24] McGill Univ, Ctr Genom & Policy, Montreal, PQ H3A 1A4, Canada

[25] Genome Quebec Innovat Ctr, Montreal, PQ H3A 1A4, Canada

[26] Univ Cambridge, Cambridge Inst Med Res, Dept Med Genet, Cambridge CB2 0XY, England

[27] Fac Med Toulouse, INSERM, U558, F-31073 Toulouse, France

[28] Univ N Carolina, Sch Pharm, Div Pharmaceut Outcomes & Policy, Inst Pharmacogen & Individualized Therapy, Chapel Hill, NC 27599 USA

[29] Kyoto Univ, Grad Sch Biostudies, Inst Integrated Cell Mat Sci, Inst Res Humanities, Kyoto 6068501, Japan

[30] Univ Deusto, Interuniv Chair Law & Human Genome, Bizkaia 48007, Spain

[31] Univ Oxford, Ethox Ctr, Oxford OX3 7LF, England

[32] Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA

[33] Univ Hosp Cleveland, Case Med Ctr, Ctr Human Genet, Cleveland, OH 44106 USA

[34] Univ Western Australia, Sch Surg, Nedlands, WA 6009, Australia

[35] German Canc Res Ctr, D-69120 Heidelberg, Germany

[36] Univ New S Wales, Garvan Inst Med Res, Sydney, NSW 2010, Australia

[37] Inst J Paoli I Calmettes, F-13273 Marseille, France

[38] Dana Farber Canc Inst, Belfer Inst Appl Canc Sci, Boston, MA 02115 USA

[39] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA

[40] INSERM, U991, F-35043 Rennes, France

[41] Univ Salamanca, Ctr Invest Canc, Univ Hosp, Dept Hematol, Salamanca 37007, Spain

[42] Hop Beaujon, F-92110 Clichy, France

[43] MLF Consulting, Arlington, MA 02474 USA

[44] Canadian Tumour Repository Network, Winnipeg, MB R3M 0V5, Canada

[45] Univ N Carolina, Div Med Oncol, Lineberger Comprehens Canc Ctr, Dept Internal Med, Chapel Hill, NC 27599 USA

[46] RIKEN, Ctr Genom Med, Kanagawa 2300045, Japan

[47] Int Genom Consortium, Phoenix, AZ 85004 USA

[48] Spanish Natl Canc Res Ctr, Mol Pathol Programme, Madrid 28029, Spain

[49] Tata Mem Hosp, Adv Ctr Treatment, Res & Educ Canc, Navi Mumbai 41021, Maharashtra, India

[50] Univ Verona, Dept Pathol, I-37134 Verona, Italy

来源：

NATURE | 2010年 / 464卷 / 7291期

基金：

英国惠康基金;

关键词：

SOMATIC MUTATIONS; MYELOID-LEUKEMIA; BREAST-CANCER; GENE; PATHWAYS; LANDSCAPES;

D O I：

10.1038/nature08987

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

引用

页码：993 / 998

页数：6

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