Synthesis of substituted acridinyl pyrazoline derivatives and their evaluation for anti-inflammatory activity

被引：98

作者：

Chandra, Trilok ^{[1
]}

Garg, Neha ^{[1
]}

Lata, Suman ^{[1
]}

Saxena, K. K. ^{[1
]}

Kumar, Ashok ^{[1
]}

机构：

[1] LLRM Med Coll, Div Med Chem, Dept Pharmacol, Meerut 250004, Uttar Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 05期

关键词：

Pyrazol-5-ones; Acridine; Oxadiazole; Anti-inflammatory activity; Analgesic activity; ANTICONVULSANT ACTIVITY;

D O I：

10.1016/j.ejmech.2010.01.009

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A rapid preparation of compounds (1-24), with the objective of discovering novel and potent anti-inflammatory agent. All the compounds exhibited anti-inflammatory and analgesic activities at the dose 50 mg/kg p.o. The compound 1-(2',4'-Chloroacridine-9'-yl)-3-(5'-pyridine-4-yl)-(1,3,4-oxadiazol-2-yl-thiomethyl)-pyrazole-5-one 24 showed better anti-inflammatory and analgesic activities at the three graded dose of 25, 50 and 100 mg/kg p.o. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：1772 / 1776

页数：5

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