Structures of photointermediates and their implications for the proton pump mechanism

被引：23

作者：

Kataoka, M

Kamikubo, H

机构：

[1] Nara Inst Sci & Technol, Dept Mat Sci, Nara 6300101, Japan

[2] High Energy Accelerator Res Org, Inst Mat Struct Sci, Tsukuba, Ibaraki 3500801, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2000年 / 1460卷 / 01期

关键词：

bacteriorhodopsin; structure of photointermediate; X-ray diffraction; proton pump mechanism; light-induced conformational change;

D O I：

10.1016/S0005-2728(00)00137-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is widely accepted that bacteriorhodopsin undergoes global conformational changes during its photocycle. In this review, the structural properties of the M and N intermediates are described in detail. Based on the clarified global conformational change, we propose a model for the molecular mechanism of the proton pump. The global structural change is suggested to be a key component in establishing vectorial proton transport. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：166 / 176

页数：11

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